Respiratory depression could be the Main hazard from all opioid agonist preparations. Respiratory depression happens most often in aged or debilitated patients, generally subsequent big Preliminary doses in non-tolerant sufferers, or when opioids are presented in conjunction with other agents that depress respiration.

The concomitant utilization of OXYCONTIN and CYP3A4 inducers can lower the plasma concentration of oxycodone [see Medical PHARMACOLOGY], leading to decreased efficacy or onset of a withdrawal syndrome in people which have created Actual physical dependence to oxycodone [see WARNINGS AND PRECAUTIONS].

Oxycodone hydrochloride tablets incorporate oxycodone, a mu-agonist opioid on the morphine type and is particularly a Timetable II controlled compound. Oxycodone hydrochloride tablets, like other opioids used in analgesia, might be abused and is also matter to felony diversion.

When this medication is made use of for a very long time, it may not get the job done too. Talk with your health practitioner if this medication stops Functioning perfectly.

Before you begin getting this medication, check with your physician or pharmacist if you ought to end or modify how you use your other opioid medication(s).

The analgesic ingredient, oxycodone, can be a semi-artificial narcotic with numerous actions qualitatively just like These of morphine; quite possibly the most well known of those will involve the central here anxious program and organs composed of smooth muscle.

Population pharmacokinetic analyses done inside the clinical research assistance The dearth of gender impact on the pharmacokinetics of oxycodone from oxycodone hydrochloride tablets.

When OXYCONTIN therapy is initiated, discontinue all other opioid analgesics aside from People made use of on an as needed foundation for breakthrough agony when correct.

The use of OXYCONTIN will not be proposed for individuals using MAOIs or within 14 days of halting these treatment method.

The concomitant usage of opioids with other drugs that affect the website serotonergic neurotransmitter method has resulted in serotonin syndrome.

Oxycodone provides respiratory melancholy by immediate action on Mind stem respiratory centers. The respiratory melancholy includes a reduction from the responsiveness in the Mind stem respiratory centers check here to equally will increase in CO2 stress and electrical stimulation.

There won't be any standard opioid tapering schedules that happen to be suitable for all sufferers. Superior clinical apply dictates a individual-precise want to more info taper the dose in the opioid little by little. For people on OXYCONTIN who are bodily opioid-dependent, read more initiate the taper by a small sufficient increment (e.

To reduce the chance of dizziness and lightheadedness, stand up little by little when rising from the sitting or lying place.

Oxycodone was genotoxic in the in vitro mouse lymphoma assay. Oxycodone was negative when analyzed at ideal concentrations during the in vitro chromosomal aberration assay, the in vitro bacterial reverse mutation assay (Ames test), as well as in vivo bone marrow micronucleus assay in mice.